Silencing the
virus within
L1 Therapeutics is developing precision therapies that suppress LINE-1 - an ancient virus-like element in the human genome that reactivates under stress and contributes to disease
Targeting LINE-1, an ancient virus-like element in the human genome
When LINE-1 reactivates under stress, it drives genomic instability and an innate immune reaction. Because LINE-1 stays quiet in healthy tissue, inhibitors primarily target disease-causing cells
Therapeutic strategy
New technology now lets us identify diseases where LINE-1 activity is treatable. We focus on conditions that show genomic signs of ongoing, active LINE-1 biology contributing significantly to disease
Short reads on LINE-1 biology
Open-source retrotransposon mining
retrotransposon-miner is our open-source software for finding mobile DNA insertions in genomic data. It detects insertions that earlier methods miss, including events previously thought to require long-read sequencing or that were not detectable before
View on GitHub
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Scientific, partnering, or investment inquiries
We welcome conversations with scientific collaborators and investors aligned with our mission to develop precision therapies that suppress LINE-1
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General inquiries